Lauroyl chloride synthesis method and density

Lauroyl chloride, also known as dodecanoyl chloride, is an organic compound with the chemical formula C12H23ClO.

It is obtained by the reaction of lauric acid with thionyl chloride. Thionyl chloride was added dropwise to lauric acid, heated to 75°C, stirred and reacted for 2h, then heated to 90°C and refluxed for 2h. The reaction mixture was then subjected to fractional distillation to remove excess thionyl chloride under reduced pressure, and the 146-150 ° C. (2.13-2.27kPa) fraction was collected as dodecanoyl chloride. The yield is about 80%.

This compound is mainly used as an intermediate in pharmaceutical and organic synthesis. Its physical properties include the appearance of a colorless liquid with a density of 0.946g/cm³, a melting point of -17°C, a boiling point between 134-137°C (11 mmHg), a refractive index in the range of 1.444-446, a flash point of 140°C, and an insolubility in water. These physical and chemical properties together define the basic characteristics of lauroyl chloride, so that it has a certain application value in the chemical industry.